Center for Human Genetics/Genomics established at UCSD


A Center for Human Genetics/Genomics has been established at UCSD, with a strong scientific base designed to translate the promise offered by knowledge of the human genome into new medical tools for diagnosis and treatment geared to an individual’s specific genetic makeup.

Established in UCSD Health Sciences, which includes the School of Medicine and School of Pharmacy and Pharmaceutical Sciences, the center brings together UCSD faculty from multiple campus departments and schools including medicine, pharmacy, biology, biostatistics and mathematics.

“If we can identify what it is about defective genes that causes them to create disease,” said Dr. Edward Holmes, UCSD vice chancellor for Health Sciences and dean of UCSD School of Medicine, “then we can develop strategies to potentially correct those defects. Taking advantage of the unparalleled opportunities presented by this post-genomic era, the center will help us better manage human disease by understanding its genetic basis.”

Because most problems and research questions in biological and biomedical sciences require the implementation of a coordinated genetic and genomic approach, the new center transcends departmental boundaries to bring together scientists from various disciplines to make modern genetics and genomic research a primary focus at UCSD.

Palmer Taylor, associate vice chancellor for Health Sciences and dean of the School of Pharmacy and Pharmaceutical Sciences, said the center’s strong scientific base will define the role genetics plays in human disease and the efficacy of pharmacotherapy.

Traditionally, genetics has meant the study of inheritance of characteristics that lead to individual differences or even disease. Often, it involves the investigation of the function of a specific gene and its effects in the body. The continuum of recent findings regarding human genes has led to the term genomics, which is the study of the function and interactions of all genes in the DNA.

The new center will embrace gene studies for both single-gene diseases such as Huntington’s disease and those illnesses caused by multiple genes, such as schizophrenia.

The Human Genome Project has led to an understanding about how human genes are organized. This has paved the way for more sophisticated efforts to understand how genes work and why genes do what they do.

“This is what we are investigating,” said the center’s director, Dr. Anthony Wynshaw-Boris, UCSD professor of pediatrics and medicine and chief of the genetics division in the Department of Pediatrics. “If we can identify what it is about defective genes that causes them to create disease, then we can develop strategies to potentially correct those defects.”

Joining Wynshaw-Boris are center co-directors professor Dr. Daniel O’Connor and Nicholas Schork, professor of psychiatry and biostatistics. The research interests of the director and co-directors are examples of UCSD’s strength in genetics.

Wynshaw-Boris focuses on understanding the genetic and biochemical pathways that are disrupted in human genetic disease during prenatal and early childhood, resulting in birth defects. By understanding what goes wrong during development in tissues such as the brain, his research group hopes to prevent tragic malformations and mental retardation.