Research Report: Hormone fights fat with fat

By Lynne Friedmann

There are two types of body fat: white fat that stores energy and brown fat (packed with blood vessels and mitrochondria) that burns white fat. Long thought to disappear after infancy, brown fat has been rediscovered in adults humans using new imaging technology.

Sanford-Burnham Medical Research Institute researchers now report the discovery of orexin; a hormone that activates calorie-burning brown fat in mice. Orexin deficiency is associated with obesity, suggesting that supplemental orexin could lead to a new class of fat-fighting drugs focused on peripheral fat-burning tissue rather than the brain’s appetite control center which is the aim of most current weight-loss agents.

The research was conducted at Sanford-Burnham’s Diabetes and Obesity Research Center, in Orlando, Fla., and is reported in the journal Cell Metabolism. News release at bit.ly/okWXeh.

Immune memory where it is needed most

La Jolla Institute for Allergy & Immunology researchers have identified a mechanism that generates protective immune “memory cells” at the body’s mucosal linings, the main entry points for many viruses and other infectious organisms.

The discovery involves a distinct process by the body for establishing strong immunity at the mucosal borders — found in the mouth, intestines, lungs, and other areas — and identification of a molecule that shows when mucosal protective immune cells are in place.
The generation of pre-existing immune memory is the basis for successful vaccination.

Heretofore, the protective quality of most vaccines has been judged by a robust memory T cell response in the blood and lymph nodes which doesn’t necessarily mean protective immunity has been generated in the intestines or at other mucosal borders.

The team conducted experiments in mouse models using Listeria, currently in the news as the bacterial agent in a number of cantaloupe-contamination deaths. Findings are published in the journal Nature Immunology. News release at bit.ly/oDXuID.

High-but-normal blood pressure a stroke risk

High blood pressure (hypertension) is a major risk factor for cardiovascular disease and strokes, but less is known about the health threat posed by “prehypertension,” is clinical category created in 2003 to describe patients whose blood pressure is elevated, but still within normal range.

New insights are now available via a meta-analysis by researchers at the UCSD School of Medicine of published scientific literature seeking to determine the extent of prehypertension risk and whether particular characteristics were associated with higher stroke risk. Their findings: People with prehypertension have a 55 percent higher risk of experiencing a stroke than people without prehypertension.

Combined, the studies reviewed involved more than 518,000 participants from the United States, Japan, China, and India. The results of the analysis held regardless of sex, race-ethnicity, blood pressure type (systolic or diastolic), or the type of stroke documented. Findings published in the journal Neurology. News release bit.ly/qlJTri.

Lynne Friedmann is a science writer based in Solana Beach.

Related posts:

  1. Research Report: Stress signal in cancer cells aids tumor growth
  2. Research Report: A ‘twist’ found in tumor metastasis
  3. Research Report: Finding may help end itching caused by meds
  4. Research Report: Ever heard of the ‘couch potato mouse’?
  5. Research Report: Find may help overcome antibiotic-resistant bacteria

Short URL: http://www.lajollalight.com/?p=52060

Posted by Staff on Oct 12, 2011. Filed under Health & Science, Research Report. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry

1 Comment for “Research Report: Hormone fights fat with fat”

  1. It's great research. Thanks for sharing.

Leave a Reply

Bottom Buttons 1

Bottom Buttons 2

Bottom Buttons 3

Bottom Buttons 4

Bottom Buttons 5

Bottom Buttons 6

RSS North Coastal News

  • Leave no one behind in Alzheimer’s research July 30, 2014
    Today in the U.S., more than 5 million people are living with mild to moderate Alzheimer’s disease. According to a 2009 study by the Alzheimer’s Association, of those 5 million people, more than 500,000 live in California. As we live longer, rates of Alzheimer’s disease have grown dramatically, and the disease is now cited as the third leading cause of death […]
  • SD Foundation announces $47M in grants, names new board members July 29, 2014
    The San Diego Foundation today announced it granted $47 million to nonprofit organizations in fiscal year 2014. Since its inception, the foundation has granted $880 million to serve and improve the San Diego region. […]
  • SD Surf Academy Condliffe GU11 win Albion Cup July 29, 2014
    San Diego Surf Academy Condliffe GU11 won the Albion National Soccer Cup championship, held July 18-21 in San Diego. […]